Will (Eric McCormack) a gay lawyer and Grace (Deborah Messing) a straight interior designer are best friends. When Grace's engagement falls apart she moves into Will's Manhattan apartment as a temporary solution. But before they know it they have become roommates in a much more permanent sense. Will's flamboyant pal Jack (Sean Hayes) and Grace's hard-drinking divorcee receptionist Karen (Megan Mullally) ensure that Will and Grace's lives never get too quiet.